---
title: How do I add, modify, or delete HPO terms in my analysis?
description: Learn how to manage patient HPO terms. This guide covers manual input, DiagAI-powered text extraction from clinical notes, and file imports, explaining where to find the HPO form at every stage of the analysis process.
---
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# How do I add, modify, or delete HPO terms in my analysis?
## A guide to managing Human Phenotype Ontology (HPO) terms at any stage of your workflow—during upload, before analysis, or after variant calling.
Human Phenotype Ontology (HPO) terms are essential for germline analysis, as they allow the platform to correlate a patient’s clinical presentation with detected genetic variants. Within Germline projects, you can manage these terms at several different stages of your workflow.
### 🕒 When can I Manage HPOs?
You have three primary opportunities to add or update HPO data for a patient:
1. **During Sample Upload:** When initially providing sample files to the platform.
2. **Before Analysis:** After the sample is uploaded but before triggering the analysis pipeline.
3. **After Analysis:** From the Analysis panel, once the variant calling and initial scoring are complete.
🛠️ Methods for HPOs input
Regardless of when you choose to input or modify HPOs, the same form is used and offers three convenient methods:
- **One by One:** Manually type the phenotype name or HPO ID and select it from the dropdown list.
- **Extract from Clinical Notes:** Click **"Extract HPOs with DiagAI"** and the tool will detect and highlight clinical terms within your notes. You can then review the suggested HPO IDs and either **"Add all"** or select specific terms to include.
- **Import from File:** Use **"Import HPOs from file"** to upload a `.txt` or `.csv` file containing the relevant HPO terms.
### 📍 Step-by-Step Location Guide
Here is where to access the HPO form at each stage of the process:
#### 1. During Sample Upload
- After uploading your sample files, click **"Next step"** to access the **"2. Set metadata"** tab.
- In the **HPO section**, click the **"+ Add"** button to open the input form.
#### 2. Before Analysis (From the Project's Samples Tab)
- Navigate to the **Samples** tab within your project.
- Select the specific sample you wish to update.
- Click **"Edit sample"** at the top right of the table, then click **"Edit"** in the HPO section.
- **Important:** Once finished, click **"Save changes"**.
#### 3. After Analysis (From the Analysis Panel)
- Be sure to have the relevant analysis open (any tab will work).
- Open the **Analysis panel** (located on the right side of the screen), and navigate to the **HPO tab.**
- The full HPO input form and extraction options are available here.
**Note:** If you modify HPOs *after* an analysis has been completed, a blue banner will appear offering to refresh the **DiagAI score**, the **HPO Phenotypes filter**, and the **Phenotype column**. For more details on this step, see [How do I update DiagAI scores with new HPO terms?](https://hubspot.seqone.com/knowledge-base/how-do-i-update-diagai-scores-with-new-hpo-terms?hsLang=en)
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