---
title: "How do I interpret the ClinVar annotation in SeqOne’s \"ClinVar Germline\" column?"
description: Learn how to interpret ClinVar annotations on the SeqOne platform. Understand pathogenicity classes, submission details, and pictograms for your genomic variants.
---
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# How do I interpret the ClinVar annotation in SeqOne’s "ClinVar Germline" column?
## Decoding ClinVar information and pictograms in SeqOne
The "ClinVar Germline" column on the SeqOne platform provides valuable information about your variants, drawn directly from the ClinVar database. This helps you understand the potential significance of a variant.
- **Classification:** aggregated from all ClinVar submissions
- **Submission Details:** You can see how many submissions support each ACMG (American College of Medical Genetics and Genomics) classification.
- **Review Status:** This star-based scale indicates the level of records and review in ClinVar.
- **Preferred Condition/Disease:** ClinVar's primary associated disease or condition for the variant.
### **Access More Details**
Want to dive deeper? Simply **click** on the information within the "ClinVar Germline" cell in your variants table. This will take you directly to the corresponding page on the official ClinVar website for more comprehensive details.
### **Understanding the Pictograms**
SeqOne uses intuitive icons to quickly convey the ClinVar pathogenicity class.
For further details on ClinVar's review statuses and classifications, you can visit the official NCBI ClinVar documentation:
- Review status: [https://www.ncbi.nlm.nih.gov/clinvar/docs/review\_status/](https://www.ncbi.nlm.nih.gov/clinvar/docs/review_status/)
- Pathogenicity class: [https://www.ncbi.nlm.nih.gov/clinvar/docs/clinsig/](https://www.ncbi.nlm.nih.gov/clinvar/docs/clinsig/)
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