Spring 2026 🌱 Somatic Pipelines

🧹 Triallelic Site Handling: The hard filter excluding triallelic sites has been removed from SomaLBx. A combination of Sentieon-recommended QUAL filters is now applied instead to keep results clean. Filtered-out variants remain accessible in a dedicated "discarded" file in the Files tab.
🔬 Improved Fusion Detection Sensitivity: We have improved the sensitivity of fusion detection in SomaLBx, for more comprehensive coverage of clinically relevant fusion events.
🔗 Fusion Calling: We have extended the list of genomic regions considered for SomaLBx fusion calling to provide more sensitive and comprehensive detection of these critical events.

👁️ Large Variants Viewer for SomaCGP: We are introducing a "first look" at the Large Variant Viewer for SomaCGP. While currently only featuring Germline columns (Somatic-specific features are on the way), you can already have a glance at the viewer, and use the active VKB to add variants to your selection and reports.
🧐 New QC Indicators in SomaCGP: Ploidy and Purity values in the QC report will now display a clear flag for issues, such as extreme ploidy levels, that might impact CNV calling accuracy.

📊 Enhanced SomaCGP and SomaLBx Metrics: The CNVs & SVs viewer now reports logRatios alongside Copy Number values, providing a more complete picture for structural event interpretation.
Reporting improvement for Somatic analyses: the columns of the automated Variant Details tables of the report (for Selected variants) have been updated to display more relevant information.